Nina Rettich
Papers
1
Total Citations
22
H-Index
1
About
Nina Rettich is a biophysical scientist whose work bridges the gap between protein formulation and advanced analytical imaging. Her research centers on the characterization of monoclonal antibody (mAb) aggregates, with a particular focus on sub-visible particles—a critical quality attribute in biopharmaceutical development. Rettich’s most notable contribution is her pioneering use of automated fluorescence microscopy imaging for high-throughput analysis of these aggregates, a method that offers unprecedented speed and resolution compared to conventional light obscuration or flow imaging techniques. Her 2017 paper on this approach, which has garnered 22 citations, demonstrates how fluorescence labeling can distinguish proteinaceous particles from silicone oil droplets and other contaminants, providing deeper mechanistic insight into aggregation pathways. This work is essential for ensuring the safety and efficacy of therapeutic antibodies, particularly in the context of immunogenicity risks. Rettich’s achievements exemplify the integration of automation and image analysis into routine quality control, making her a key figure in the advancement of biophysical characterization tools for the pharmaceutical industry.
Research Focus
Key Achievements
Top Papers
- 1