Leen Sysmans
Papers
1
Total Citations
64
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1
About
Leen Sysmans is a pharmaceutical scientist whose work has significantly advanced the field of drug discovery, particularly in the area of preclinical ADME (absorption, distribution, metabolism, and excretion) profiling. Her primary research focus is on developing and validating high-throughput bioanalytical assays to improve the efficiency and reliability of early-stage drug candidate screening. Her most impactful contribution is the development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding, a critical parameter that influences a drug's pharmacokinetics and efficacy. This seminal work, which has garnered 64 citations, details a semiautomated method capable of measuring 32 plasma protein binding samples per screen, dramatically increasing laboratory throughput while maintaining data quality. By addressing the practical challenges of assay development, Sysmans provided the pharmaceutical community with a robust, flexible tool that has become a standard in many drug discovery pipelines. Her work exemplifies the crucial role of method development in accelerating the identification of promising therapeutic candidates.
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Top Papers
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