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About

Denise Morrison is a pioneering bioanalytical scientist whose career has been defined by transforming pharmacokinetic and bioanalytical workflows in drug discovery through automation and high-throughput innovation. Her most influential contribution, a 2000 paper garnering 119 citations, introduced a groundbreaking redesign of protein precipitation assays into a 96-well microtiter plate format coupled with robotic liquid handling and LC–MS/MS detection — a methodology that fundamentally accelerated how drug concentrations in plasma are measured within discovery pipelines. This work, alongside her equally influential 2000 paper on higher-throughput pharmacokinetics (HTPK) approaches, helped establish the conceptual and practical framework for rapid in vivo screening that the pharmaceutical industry now takes for granted. Morrison further demonstrated her commitment to rigorous, scalable science through her 2011 development and validation of a semiautomated plasma protein binding assay, cited 64 times, which brought reproducibility and throughput to a notoriously variable measurement. Collectively, her contributions span automated sample preparation, plasma protein binding, and systems-level pharmacokinetics, making her a foundational figure in the modernization of early-stage drug discovery bioanalysis.