Paul Nelis
Papers
1
Total Citations
64
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1
About
Paul Nelis is a leading figure in bioanalytical chemistry, with a primary focus on advancing the methodologies used to measure drug–protein interactions. His most influential contribution is the development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding (PPB), a critical parameter in pharmacokinetics. Detailed in his seminal 2011 paper, which has garnered 64 citations, Nelis’s work transformed a traditionally low-throughput, labor-intensive process into a semiautomated system capable of handling 32 PPB measurements per screen using triplicate incubations. This innovation dramatically increased efficiency and reproducibility in early drug discovery, enabling researchers to screen more compounds with greater accuracy. By addressing a key bottleneck in preclinical development, Nelis’s assay has become a standard reference in the field, underscoring his impact on streamlining the path from candidate selection to clinical testing. His work remains essential for scientists seeking reliable, high-capacity tools to evaluate drug binding properties.
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