Kelly M. Jenkins

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About

Kelly M. Jenkins is a leading figure in drug discovery and development, whose work has significantly advanced the field of preclinical ADME (Absorption, Distribution, Metabolism, and Excretion) profiling. Her research focuses on creating high-throughput methodologies to assess drug metabolism and safety, bridging the gap between combinatorial chemistry and clinical viability. Jenkins is best known for her seminal 2004 paper, "Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries," which has garnered 87 citations and established a foundational protocol for rapidly evaluating large compound libraries. This work revolutionized early-stage drug screening by enabling researchers to predict metabolic stability and potential drug-drug interactions with unprecedented efficiency. Her contributions have been instrumental in reducing late-stage drug attrition, saving both time and resources in pharmaceutical R&D. Jenkins’s innovative integration of automation and ADME science continues to influence modern drug discovery pipelines, making her a pivotal figure for students and researchers interested in translational pharmacology and the practical challenges of bringing new therapies to market.