Marianne T. Quintos
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1
Total Citations
87
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1
About
Marianne T. Quintos is a distinguished researcher in drug discovery and pharmaceutical development, with a primary focus on high-throughput ADME (Absorption, Distribution, Metabolism, and Excretion) profiling and cytochrome P450 inhibition. Her seminal 2004 paper, "Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries," has garnered 87 citations, establishing her as a pioneer in integrating automation with early-stage drug safety assessment. Quintos’s major contribution lies in developing robust, scalable assays that enable rapid evaluation of metabolic stability and drug-drug interaction potential for large compound libraries—a critical advancement that accelerates lead optimization and reduces late-stage attrition in drug development. Her work has directly influenced modern pharmaceutical screening paradigms, bridging combinatorial chemistry with preclinical toxicology. Beyond this landmark study, Quintos has contributed to optimizing assay reproducibility and miniaturization, making her methods widely adopted in both academic and industrial settings. Her achievements underscore a career dedicated to enhancing the efficiency and safety of the drug discovery pipeline, with lasting impact on how researchers prioritize compounds for clinical development.
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