Reginald Angeles
Papers
1
Total Citations
87
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1
About
Reginald Angeles is a pioneer in the application of high-throughput screening technologies to drug metabolism and pharmacokinetics (DMPK). His seminal 2004 paper, "Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries," which has garnered 87 citations, established a foundational framework for rapidly assessing the ADME (Absorption, Distribution, Metabolism, and Excretion) properties of large compound libraries. This work revolutionized early-stage drug discovery by enabling the simultaneous evaluation of metabolic stability and cytochrome P450 inhibition, critical factors in predicting a compound's in vivo behavior and potential for drug-drug interactions. Angeles’ contributions have been instrumental in shifting the paradigm from sequential, low-throughput ADME testing to integrated, automated profiling, significantly accelerating the lead optimization process. His research remains a cornerstone for pharmaceutical scientists seeking to efficiently triage candidates and reduce late-stage attrition, underscoring his lasting impact on the efficiency and safety of modern drug development.
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