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Jamie Rossjohn is a leading structural biologist whose research has profoundly advanced our understanding of the molecular mechanisms underlying immunity, infection, and cancer. His work is characterized by the use of high-resolution X-ray crystallography to visualize how proteins interact at the atomic level. A key contribution is his pioneering research on the tumor suppressor Maspin, where his team solved its high-resolution crystal structure, revealing a novel conformational switch in the G-helix (83 citations). This landmark study provided critical insight into Maspin’s function, a serpin essential for development and implicated in breast and lung cancers. Beyond cancer biology, Rossjohn is renowned for his extensive work on T-cell receptor recognition and the structural biology of the immune system, including major histocompatibility complex (MHC) molecules and natural killer cell receptors. His research has been instrumental in deciphering how the immune system distinguishes self from non-self, with implications for autoimmune disease, transplant rejection, and vaccine design. With a publication record that includes numerous papers in top-tier journals and tens of thousands of citations, Rossjohn’s work has fundamentally shaped modern structural immunology.