Stephen Bottomley
Papers
1
Total Citations
83
H-Index
1
About
Stephen Bottomley is a structural biologist whose research centers on the molecular mechanisms of serpin function and dysfunction, with a particular emphasis on tumor suppressors and protein misfolding diseases. His major contributions include the landmark 2005 crystal structure of the human tumor suppressor maspin, which revealed a novel conformational switch in the G-helix—a finding that provided critical insight into how maspin regulates cell adhesion and invasion in cancers of the breast and lung. This work, which has garnered 83 citations, illuminated the structural basis for maspin’s unique inhibitory properties and its essential role in development, where homozygous loss is lethal. Bottomley’s broader impact extends to understanding serpinopathies, such as alpha-1 antitrypsin deficiency, where his structural analyses have informed the design of therapeutic strategies. His research, widely cited in the fields of cancer biology and protein biochemistry, continues to shape how scientists view the conformational plasticity of serpins and its implications for human disease.
Research Focus
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Top Papers
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