Gustavo Fenalti

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About

Gustavo Fenalti is a structural biologist whose work has significantly advanced our understanding of protein crystallization and its role in drug discovery. His research focuses on the structural biology of G protein-coupled receptors (GPCRs) and other membrane proteins, with a particular emphasis on developing novel crystallization strategies to solve challenging protein structures. Fenalti's major contributions include pioneering methods for stabilizing and crystallizing GPCRs in different conformational states, enabling the determination of high-resolution structures that were previously considered intractable. His work has been instrumental in revealing the molecular mechanisms of receptor activation and allosteric modulation, with his most cited papers collectively garnering thousands of citations. Notably, Fenalti was part of the team that solved the first structure of the nociceptin/orphanin FQ receptor, a breakthrough that opened new avenues for pain therapeutics. His early work on managing and mining protein crystallization data (2005, 3 citations) laid the groundwork for high-throughput structural biology approaches. Through his innovative crystallization techniques and structural insights, Fenalti has become a leading figure in GPCR structural biology, bridging fundamental receptor biology with practical applications in pharmaceutical development.