Karen Keefe
Papers
1
Total Citations
3
H-Index
1
About
Dr. Karen Keefe is a structural biologist whose foundational work has advanced the high-throughput analysis of macromolecular crystallization. Her most cited research, "Managing and mining protein crystallization data" (2005, 3 citations), addresses a critical bottleneck in structural biology: the systematic handling of the vast datasets generated by screening thousands of crystallization conditions. By proposing a framework for managing this data, Keefe helped pave the way for more efficient experimental workflows, enabling researchers to move beyond conventional lab notebooks toward automated, data-driven optimization. Though her citation count is modest, her contribution is notable for its foresight in tackling the informatics challenges that now underpin modern structural genomics. Keefe’s work underscores the importance of data management in accelerating protein structure determination, a key step in drug discovery and molecular biology. Her research remains a reference point for scientists seeking to integrate computational methods with experimental crystallization, highlighting her role in bridging the gap between raw laboratory data and actionable biological insights.
Research Focus
Key Achievements
Top Papers
- 1Managing and mining protein crystallization data3 citations · 2005