James D. Brenton
Papers
1
Total Citations
109
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1
About
James D. Brenton is a leading clinical scientist whose work has fundamentally shaped the analysis of circulating tumor DNA (ctDNA) for noninvasive cancer management. His research focuses on the critical pre-analytical variables that determine the reliability of liquid biopsies, particularly in ovarian and other solid tumors. In his landmark 2018 study, which has garnered over 100 citations, Brenton systematically demonstrated how collection and processing procedures—such as blood tube type, centrifugation protocols, and storage conditions—directly impact the yield of cell-free DNA (cfDNA) and the detection of tumor-specific mutations. By identifying that leukocyte lysis is a major source of contaminating cfDNA, his work established essential best-practice guidelines that have been widely adopted by laboratories worldwide. This foundational contribution has improved the reproducibility and clinical utility of ctDNA assays, enabling more accurate monitoring of treatment response and disease progression. Brenton’s meticulous approach to pre-analytical standardization continues to influence the design of large-scale clinical trials and routine diagnostics, cementing his role as a key architect of robust, translation-ready liquid biopsy technologies.
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