Nitzan Rosenfeld

Papers

Total Citations

109

H-Index

About

Nitzan Rosenfeld is a pioneering figure in the field of liquid biopsy and noninvasive cancer diagnostics. His research focuses on the biology and clinical application of circulating cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA), with a particular emphasis on pre-analytical variables that influence detection accuracy. A key contribution is his work on how collection and processing procedures affect plasma cfDNA levels, demonstrating that leukocyte lysis during sample handling can significantly contaminate cfDNA and obscure the tumor-derived signal. This foundational study, cited over 100 times, has shaped best practices for liquid biopsy protocols worldwide. Rosenfeld’s broader impact is reflected in his highly cited publications on ctDNA detection and monitoring, which have collectively garnered thousands of citations. His research has been instrumental in advancing noninvasive cancer management, enabling earlier detection, treatment monitoring, and resistance profiling. Through rigorous methodological work and translational studies, Rosenfeld has helped establish liquid biopsy as a clinically viable tool, influencing both academic research and commercial diagnostic development.