Jacques Crommen
Papers
7
Total Citations
173
H-Index
7
About
Jacques Crommen is a distinguished analytical chemist whose career has been defined by pioneering advances in automated bioanalytical methods, with a particular focus on high-performance liquid chromatography (HPLC) and sample preparation techniques for pharmaceutical compounds in biological matrices. Working primarily throughout the 1990s, Crommen made significant contributions to the development of fully automated systems coupling solid-phase extraction, dialysis, and liquid-solid extraction with HPLC, dramatically improving the efficiency and sensitivity of drug analysis in human plasma. His most celebrated work—the automated determination of tramadol enantiomers using chiral liquid chromatography, which has garnered 66 citations—exemplifies his expertise in enantioselective analysis, a critical area in pharmacokinetics and drug safety. His innovative use of on-line dialysis coupled to chiral reversed-phase HPLC, demonstrated through studies on verapamil, oxprenolol, and other cardiovascular drugs, helped establish robust methodologies for resolving drug stereoisomers directly from complex biological samples. His automated approaches to analyzing compounds such as indomethacin, diltiazem, and sulfamethazine further cemented his reputation as a methodological innovator. Crommen's work remains an essential reference for researchers developing automated pharmaceutical bioanalysis platforms.
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