Patrice Chiap
Papers
6
Total Citations
151
H-Index
6
About
Patrice Chiap is a analytical chemist whose research has made significant contributions to the development of automated chromatographic methods for pharmaceutical analysis in biological matrices. Working primarily in the 1990s, Chiap specialized in coupling sample preparation techniques — including solid-phase extraction and online dialysis — with high-performance liquid chromatography (HPLC) to enable precise quantification of drugs and their metabolites in human plasma. Among Chiap's most notable achievements is the development of automated methods for chiral separation, a technically demanding area of pharmaceutical analysis. The 1997 study on tramadol enantiomer determination using chiral liquid chromatography became the most recognized work, accumulating 66 citations and demonstrating the power of combining solid-phase extraction with enantioselective chromatography. Complementary work on oxprenolol and verapamil further cemented expertise in stereospecific drug analysis. Earlier foundational studies on diltiazem and sulfamethazine in plasma helped establish robust automated workflows that reduced manual sample handling while improving reproducibility. Chiap's body of work reflects a consistent focus on method automation, validation, and practical bioanalytical application, offering researchers reliable analytical frameworks that have informed pharmaceutical pharmacokinetic studies across cardiovascular and analgesic drug classes.
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