Gayathri Mohanan

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About

Gayathri Mohanan is a rising star in the field of DNA nanotechnology, with her work centered on advancing the synthesis and purification of DNA origami—a powerful technique for constructing nanoscale structures with precise geometries. Her major contribution, detailed in her highly cited 2023 paper "Automated Purification of DNA Origami with SPRI Beads," addresses a critical bottleneck in the field: the efficient removal of excess DNA oligos and functional molecules after synthesis. By adapting Solid Phase Reversible Immobilization (SPRI) beads for automated purification, Mohanan has introduced a scalable, reproducible, and high-throughput method that overcomes the limitations of traditional techniques like gel electrophoresis and ultrafiltration. This innovation not only streamlines the production of high-quality DNA origami but also paves the way for their broader application in drug delivery, biosensing, and nanorobotics. With 18 citations in just a short time, her work is already gaining traction, reflecting its immediate impact on the research community. Mohanan’s achievement stands out for its practical elegance, offering a simple yet transformative solution that promises to accelerate progress in DNA nanotechnology and inspire further automation in nanofabrication.