Iain C. Macaulay

Earlham Institute, University of East Anglia

Papers

Total Citations

210

H-Index

About

Iain C. Macaulay is a leading figure in single-cell genomics, whose work has fundamentally advanced our ability to dissect the molecular complexity of individual cells. His primary research focuses on developing and applying innovative methods to profile the genome and transcriptome simultaneously from the same cell. Macaulay’s most impactful contribution is the invention of G&T-seq (Genome and Transcriptome sequencing), a groundbreaking technique that enables the parallel sequencing of DNA and RNA from a single cell. This method, detailed in his highly cited 2016 paper (192 citations), allows researchers to directly link genetic variation with gene expression, providing unprecedented insights into cellular heterogeneity, development, and disease. Beyond single-cell genomics, Macaulay has also contributed to the field of DNA nanotechnology, notably co-authoring a 2023 study on an automated purification method for DNA origami using SPRI beads. His work has been instrumental in pushing the boundaries of what is possible in molecular biology, providing powerful tools that are now widely adopted by the research community to explore the fundamental biology of life at the highest resolution.