Papers
3
Total Citations
600
H-Index
3
About
Dr. F. Collart is a leading figure in structural genomics and high-throughput protein production, whose work has fundamentally advanced the tools available for molecular biology and structural determination. Their most impactful contribution is the development of a groundbreaking vector for ligation-independent cloning (LIC) that incorporates a Tobacco Etch Virus (TEV) protease cleavage site. This 2002 paper, with over 540 citations, has become a standard reference in the field, enabling efficient protein purification and streamlining the production of recombinant proteins for structural studies. Dr. Collart has further extended this methodology by creating new vectors for the co-expression of multiple proteins, a critical capability for studying macromolecular complexes, as demonstrated in their work on the *Bacillus subtilis* ScoAB protein. Their expertise in high-throughput structural biology is also evident in the determination of the crystal structure of the hypothetical protein YfiH from *Shigella flexneri*. By solving this structure of an uncharacterized conserved protein, Dr. Collart has contributed to the functional annotation of entire protein families, a cornerstone of modern genomics. Through these innovations in cloning and structural determination, Dr. Collart has provided the scientific community with essential, widely-adopted tools that continue to accelerate discovery in protein science.
Research Focus
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