William H. Eschenfeldt
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1
Total Citations
40
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1
About
William H. Eschenfeldt is a structural biologist and protein engineer whose work has advanced high-throughput methods for macromolecular crystallography. His primary research focuses on developing novel expression vectors and streamlined protocols for the co-production of protein complexes, enabling the rapid determination of three-dimensional structures. Eschenfeldt’s most cited contribution, the 2007 paper “New vectors for co-expression of proteins: Structure of Bacillus subtilis ScoAB obtained by high-throughput protocols” (40 citations), exemplifies his impact. In this work, he introduced versatile co-expression vectors that facilitate the simultaneous production of multiple proteins in a single host, a critical tool for studying multi-subunit assemblies. By applying these methods to solve the structure of the Bacillus subtilis ScoAB complex, he demonstrated how high-throughput pipelines can accelerate structural discovery. His achievements have provided the structural biology community with standardized, efficient tools that reduce bottlenecks in protein production and crystallization. Through these contributions, Eschenfeldt has helped democratize access to complex structural studies, making it easier for researchers to tackle challenging biological systems.
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Top Papers
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