Irina Dementieva
Papers
1
Total Citations
19
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1
About
Irina Dementieva is a structural biologist whose research focuses on elucidating the three-dimensional architecture of proteins to understand their biological function. Her major contributions lie in the field of X-ray crystallography, where she has specialized in solving the structures of uncharacterized or hypothetical proteins—molecules whose roles are unknown at the sequence level. Her most cited work, the 2006 paper on the crystal structure of the hypothetical protein YfiH from *Shigella flexneri*, is a landmark study in this area. Using the single wavelength anomalous dispersion (SAD) method, she determined the structure at 2 Å resolution, providing the first atomic-level view of a protein belonging to a vast and poorly understood family. This work, which has garnered 19 citations, is a foundational contribution to structural genomics, offering critical insights that help researchers infer function from form. By solving the structure of YfiH, Dementieva has enabled further studies into the roles of these conserved but enigmatic proteins, demonstrating the power of structural biology to unlock the secrets of the proteome. Her research exemplifies the meticulous craft of crystallography and its importance in advancing our fundamental understanding of cellular machinery.
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Top Papers
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