Dexuan Xiao

Papers

Total Citations

135

H-Index

About

Dexuan Xiao is a pioneering researcher at the intersection of DNA nanotechnology and precision medicine, whose work redefines how we design intelligent therapeutic agents. His primary research areas include framework nucleic acid engineering, active-targeting drug delivery, and immunomodulatory nanorobotics. Xiao’s major contributions lie in developing dynamic DNA nanostructures that mimic biological behaviors—most notably, his 2020 paper on the “Framework Nucleic Acid Based Robotic Nanobee” (95 citations), which introduced a melittin-loaded tetrahedral nanorobot capable of active targeting, inspired by honeybee defensive strategies. This work marked a paradigm shift from static DNA carriers to responsive, autonomous systems. Building on this, his 2025 study on a “DNA-based nanorobot for targeting, hitchhiking, and regulating neutrophils” (40 citations) showcases a novel approach to sepsis therapy by engineering nanorobots that harness immune cells as both transport and therapeutic partners. With over 135 combined citations for these flagship studies, Xiao’s research has been widely recognized for its translational potential. His achievements include advancing the field of DNA robotics from proof-of-concept to in vivo applications, offering new hope for treating complex diseases through programmable, biocompatible nanomachines.