Devin Oglesbee
Papers
1
Total Citations
108
H-Index
1
About
Devin Oglesbee has made foundational contributions to the understanding of mitochondrial biology, with a particular focus on the NADH dehydrogenase complex (Complex I)—a critical component of the electron transport chain. His most cited work, "The Subunit Composition of the Human NADH Dehydrogenase Obtained by Rapid One-step Immunopurification" (2003, 108 citations), introduced a novel immunocapture procedure that enabled the rapid, high-purity isolation of this multisubunit enzyme. This methodological breakthrough was pivotal, as defects in Complex I are central to mitochondrial diseases and are strongly linked to late-onset neurological disorders, including Parkinson’s disease. By clarifying the subunit composition of human Complex I, Oglesbee’s research provided a crucial tool for dissecting the molecular basis of these conditions, advancing both diagnostic approaches and therapeutic targets. His work stands as a cornerstone in mitochondrial medicine, bridging basic biochemistry with clinical neurology. Oglesbee’s contributions continue to inform studies on energy metabolism and neurodegeneration, underscoring his lasting impact on the field.
Research Focus
Key Achievements
Top Papers
- 1