Eoin Fahy
Papers
2
Total Citations
191
H-Index
2
About
Eoin Fahy is a leading figure in mitochondrial proteomics and bioenergetics, whose work has fundamentally advanced our understanding of the molecular machinery underlying human metabolism and disease. His research centers on the structural and functional characterization of the oxidative phosphorylation system, with a particular focus on the NADH dehydrogenase (Complex I) complex. Fahy’s major contributions include the development of a rapid, one-step immunopurification method to isolate the intact human Complex I, a breakthrough that enabled detailed analysis of its subunit composition and its direct link to mitochondrial disorders and late-onset neurological conditions like Parkinson’s disease. This seminal work has garnered over 108 citations. Complementing this, Fahy pioneered an alternative strategy for mapping the mitochondrial proteome using sucrose gradient fractionation and 1D PAGE on highly purified human heart mitochondria—a technique that overcame the limitations of traditional 2D PAGE and provided a more comprehensive view of mitochondrial protein content, earning 83 citations. Through these methodological innovations, Fahy has provided essential tools and insights for researchers investigating mitochondrial dysfunction, solidifying his impact on the fields of proteomics, cell biology, and neurodegenerative disease research.
Research Focus
Key Achievements
Top Papers
- 1
- 2