Roderick Capaldi
Papers
2
Total Citations
191
H-Index
2
About
Roderick Capaldi is a pioneering researcher in mitochondrial biology, with a career focused on understanding the structure, function, and dysfunction of the mitochondrial respiratory chain. His key research areas include mitochondrial proteomics, the molecular basis of mitochondrial diseases, and the role of mitochondrial defects in neurodegenerative disorders such as Parkinson’s disease. Capaldi’s major contributions include developing innovative methods for isolating and characterizing mitochondrial protein complexes. His 2003 paper on the rapid immunopurification of the human NADH dehydrogenase (Complex I) provided a groundbreaking tool for studying this critical enzyme, whose defects are linked to both inherited mitochondrial diseases and late-onset neurological conditions—a work that has garnered 108 citations. Earlier, in 2002, he introduced an alternative strategy for determining the mitochondrial proteome using sucrose gradient fractionation and 1D PAGE on highly purified human heart mitochondria, earning 83 citations. This approach complemented traditional 2D PAGE techniques and advanced the field of mitochondrial proteomics. Capaldi’s work has had a lasting impact, offering researchers essential tools to explore mitochondrial dysfunction and its implications for human health.
Research Focus
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Top Papers
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