Daniela Lepanto

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About

Daniela Lepanto is a surgical pathologist whose work sits at the intersection of urologic oncology and advanced imaging technology. Her primary research focus is the intraoperative assessment of surgical margins during robot-assisted radical prostatectomy (RARP), a critical step in ensuring complete tumor removal while preserving healthy tissue. In her landmark 2024 study, Lepanto pioneered the use of ex vivo fluorescence confocal microscopy (FCM) as an alternative to traditional intraoperative frozen section (IFS) analysis. By directly comparing FCM against both IFS and final pathology, she demonstrated that this cutting-edge, high-resolution imaging technique could match or even surpass conventional methods in accuracy, speed, and tissue preservation. This work, already cited 14 times, positions her as a key innovator in real-time pathology, with the potential to reduce positive surgical margins and improve patient outcomes. Lepanto’s contributions are particularly notable for bridging the gap between pathology and surgical practice, offering a non-destructive, digital alternative that could transform how margins are evaluated in the operating room. Her research continues to shape the future of precision surgery.