Alessandro Negro

École Polytechnique Fédérale de Lausanne

Papers

Total Citations

237

H-Index

About

Alessandro Negro is a leading researcher at the intersection of stem cell biology, tissue engineering, and high-throughput screening. His work is defined by pioneering the use of 3D microenvironments to decode how physical and biochemical cues govern cell fate. Negro’s most cited contribution, “3D niche microarrays for systems-level analyses of cell fate” (2014, 237 citations), introduced a transformative platform that recreates the complexity of native tissue microenvironments in a controlled, miniaturized format. This innovation enables systematic, high-resolution studies of how extracellular matrix signals, cell-cell interactions, and soluble factors collectively direct stem cell behavior—bridging a critical gap between traditional 2D culture and in vivo biology. By enabling systems-level analyses, Negro’s work has provided foundational tools for regenerative medicine and cancer research, allowing researchers to screen microenvironments at unprecedented scale. His contributions have been instrumental in advancing our understanding of how niche mechanics and biochemistry orchestrate cell decisions, making him a key figure in the development of next-generation 3D culture technologies.