Samy Gobaa

École Polytechnique Fédérale de Lausanne

Papers

Total Citations

651

H-Index

About

Samy Gobaa is a leading figure in the field of stem cell bioengineering, with a primary focus on understanding how the cellular microenvironment—or "niche"—governs cell fate. His most impactful work centers on the development of innovative high-throughput platforms to systematically probe these complex interactions. In his landmark 2011 paper, "Artificial niche microarrays for probing single stem cell fate in high throughput" (393 citations), Gobaa introduced a powerful tool that allows researchers to screen hundreds of microenvironmental signals simultaneously at the single-cell level. He further advanced this concept with his 2014 study on "3D niche microarrays for systems-level analyses of cell fate" (237 citations), which incorporated the critical third dimension to more accurately mimic native tissue architecture. This work demonstrated how the dynamic interplay of biochemical and mechanical signals from the extracellular matrix directs cell behavior. By creating these "live mammalian cell arrays," Gobaa has provided the stem cell community with essential tools to deconstruct the niche's complexity, enabling discoveries that bridge fundamental biology and tissue engineering.