Microbial therapeutics

摘要

This is a current review on microbial therapeutics. The review discusses additive and subtractive methods for modulating microbiota to improve health. This web page describes a project supported by the National Science Foundation and Microbial Robotics to develop engineered bacteria to release therapeutic chemicals and kill cancer cells. This is a commercial website for a company teaming up with other companies to develop microbial therapeutics. Projects include the treatment of inflammatory bowel disease and Clostridium dificile infections. This review article discusses options for replacing diseased gut microbiota with a healthy gut microbiota to restore health in human patients. This page highlights the book, Probiotics and prebiotics: Current research and future trends. This Frontiers issue deals with microbial antibiotic resistance and efforts to identify new natural products and increasingly, alternative strategies for fighting microbial infectious disease. This review article discussed faecal microbial therapy and advocates for a more comprehensive treatment of modulating the broader intestinal ecosystem. Clostridium dificile infections are being treated using faecal transplantation. This article discusses an alternative process of providing an oral pill containing spores that will pass into the intestine and modulate a healthy gut microbiota. This company provides services and products focused on analysing and treating diseased microbiomes, respectively. Evelo Biosciences, working in collaboration with the Mayo Clinic, seeks to establish immuno-microbiome cancer therapies. The use of bacteria to cause tumour regression has been investigated for decades, but recent developments in genomic sequencing and microbiome research have fuelled this area of research. This article discusses how the microbiome influences and enhances cancer chemotherapies, presumably through dealing with inflammation. The skin disorder eczema is thought to be due to an undesirable change in localized skin microbiota. In this context, a cream was made of healthy bacteria on skin to treat afflicted areas. This article highlights one companies approach in microbial therapeutics, largely from the perspective of intellectual property. This news article discussed strategies for engineering bacteria to both thrive in the intestinal tract, as well as to clear when that is desirable. This is a broad-based review on the effects of gut microbiota on modulating immune function. This news article provides an overview of modulating the human microbiome to deal with disease. The article focuses on some of the key researchers and emerging companies in the field.