Microrobotic swarms and their robotic delivery applications offer new venues for gene therapy delivery

摘要

Over the past decade, microrobotic swarms and their robotic delivery applications have evolved substantially. This review looked at the current advances in microrobotics swarming, navigation, and localization, as well as their applications for targeted imaging-guided distribution. While a substantial effort has been proposed towards in-vivo controlled administration, several restrictions remain. Research opportunities and challenges are presented, with probable solutions on the horizon. Microrobotic Swarm, Controller and Integration of Imaging Modality. Integrating the swarm controller with in vivo imaging technologies is a requirement for in vivo delivery jobs. Trading between imaging and control systems, as well as developing a swarm control scheme based on current imaging systems, is hard to do. Research should focus on integrating swarm navigation and imaging into the same energy source. The toxicity threshold needed depends on where microrobotic swarms are employed. Before establishing therapeutic procedures, the swarms' biocompatibility and toxicity should be evaluated. Swarms in endovascular delivery applications may require a more complete toxicity evaluation, including a range of parameters such as materials, dose, and block size. Research opportunities include bridging customized therapy/delivery and imaging-guided swarm control.