Zhifei Xu
Papers
2
Total Citations
154
H-Index
2
About
Zhifei Xu is a pioneer at the intersection of DNA nanotechnology and synthetic biology, with a primary focus on engineering nongenetic, programmable systems to control cellular behavior. Their most impactful work introduces a logic-gate-actuated, DNA-controlled receptor assembly platform that enables the programmable modulation of cellular signal transduction. This breakthrough allows cells to sense multiple molecular inputs and activate downstream signaling cascades without relying on genetic circuits—a long-sought goal in the field. By using DNA as a generic, modular tool to orchestrate receptor clustering, Xu’s approach offers a versatile, nongenetic strategy for rewiring cell communication, with profound implications for therapeutic engineering and smart biomaterials. Their flagship 2019 publication has garnered over 124 citations, underscoring its influence as a foundational method for dynamic cell control. Xu’s work stands out for its elegant fusion of DNA logic and cell-surface engineering, providing a powerful alternative to traditional synthetic biology. This achievement marks Xu as a leading innovator in nongenetic cellular programming, opening new avenues for precision medicine and bioresponsive systems.
Research Focus
Key Achievements
Top Papers
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- 2