Zhangyan Guan
Papers
3
Total Citations
55
H-Index
3
About
Zhangyan Guan is a pioneering researcher at the intersection of robotics, nanotechnology, and genetic engineering, whose work is redefining precision medicine. Her primary research areas include automated intracellular delivery, CRISPR/Cas9 gene editing, and stem cell engineering. Guan’s major contribution is the development of a robot-aided microscope system with three-dimensional image reconstruction, enabling precise, automated delivery of biomolecules into single cells—a breakthrough for applications like genome editing and intracellular mechanism studies. Her 2020 paper on this system has garnered 27 citations, reflecting its impact on the field. In 2022, she advanced gene therapy by demonstrating high-throughput microinjection of the CRISPR/Cas9 system for knock-in of large reporter genes, a non-viral approach that overcomes limitations of traditional chemical and physical methods. Her 2021 study on gene delivery to mesenchymal stem cells further highlights her commitment to optimizing cell-based therapies, showing that microinjection preserves differentiation potential better than viral or chemical methods. Guan’s work is notable for its translational potential, offering scalable, precise tools for both fundamental research and clinical applications in gene therapy and regenerative medicine.
Research Focus
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Top Papers
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