Papers
1
Total Citations
76
H-Index
1
About
Ze Shi is a leading figure in DNA nanotechnology, whose work centers on engineering dynamic, reconfigurable molecular systems. His major contribution lies in pioneering cation-activated avidity as a powerful strategy for controlling the behavior of DNA nanodevices. In his highly cited 2018 paper (76 citations), Shi demonstrated how specific cations can rapidly and reversibly trigger conformational changes in DNA nanostructures, enabling precise, on-demand control over their function. This breakthrough provides a robust foundation for molecular-scale robotics, with direct implications for nanomanufacturing, targeted drug delivery, and the regulation of enzymatic reactions. By moving beyond traditional strand-displacement methods, Shi’s approach offers a simpler, faster, and more reversible actuation mechanism, significantly advancing the field’s ability to create responsive nanomaterials. His work is not only foundational for designing smarter nanodevices but also inspires new avenues for integrating DNA-based machinery into real-world biomedical and technological applications.
Research Focus
Key Achievements
Top Papers
- 1Cation-Activated Avidity for Rapid Reconfiguration of DNA Nanodevices76 citations · 2018