Yuanyuan Chang
Papers
1
Total Citations
69
H-Index
1
About
Yuanyuan Chang has made pioneering contributions to the field of DNA nanotechnology and biosensing, with a particular focus on designing intelligent DNA nanomachines for ultrasensitive molecular detection. Her key research areas include DNA walking nanomachines, electrochemical biosensors, and multiplexed sensing platforms for disease-related biomarkers. In her most highly cited work (69 citations), Chang introduced a remarkably simple yet highly efficient classified cargo-discharge DNA robot constructed from only two DNA strands. This innovative nanomachine, driven by an analogous proximity ligation assay-based enzyme cleavage mechanism, enabled fast, autonomous walking along a DNA track. She demonstrated its power by developing an electrochemical biosensor capable of simultaneously detecting microRNA-155 and other targets with exceptional sensitivity. This work stands out for its elegant minimalism—achieving complex, programmable behavior with unprecedented structural simplicity—and its practical impact on multiplexed diagnostics. Chang’s research bridges fundamental DNA nanoscience and real-world biomedical applications, offering a versatile platform for early disease detection. Her contributions continue to inspire new directions in smart nanomachine design and high-performance biosensing.
Research Focus
Key Achievements
Top Papers
- 1