Yoshihide Hayashizaki
Papers
2
Total Citations
30
H-Index
2
About
Yoshihide Hayashizaki is a pioneering figure in functional genomics, best known for his foundational contributions to transcriptome analysis and promoter biology. His research has centered on developing and refining technologies for comprehensive gene expression profiling, particularly through Cap Analysis of Gene Expression (CAGE). Hayashizaki’s major contributions include advancing CAGE from a conceptual method into a robust, high-throughput workflow compatible with single-molecule sequencing, as demonstrated in his 2012 paper detailing an automated preparation pipeline for the HeliScope sequencer (27 citations). This work enabled precise, genome-wide mapping of transcription start sites and their expression levels, providing an unprecedented view of promoter architecture and regulation. Beyond technical innovation, Hayashizaki has been a vocal advocate for open science and resource sharing, co-authoring the influential 2004 perspective “The Responsibility to Share,” which outlined ethical and practical frameworks for distributing novel biological resources like transcriptome and promoterome clone sets. His leadership in large-scale consortium projects, such as FANTOM, has further cemented his legacy, generating foundational datasets that continue to drive discovery in gene regulation and disease biology.
Research Focus
Key Achievements
Top Papers
- 1
- 2The Responsibility to Share: Sharing the Responsibility3 citations · 2004