Yiyan Yu

Papers

Total Citations

150

H-Index

About

Yiyan Yu is a pioneering researcher in biohybrid microrobotics, with a focus on developing living microrobots for targeted drug delivery in cancer and inflammatory diseases. Their major contributions include the design of algae-based biohybrid systems that actively transport drug-loaded nanoparticles to treat challenging conditions like lung metastasis and inflammatory bowel disease (IBD). In their 2024 study on lung metastasis, Yu demonstrated that motile algae microrobots could locally deliver nanoparticles to inhibit disease progression, achieving 84 citations for its innovative approach to overcoming poor drug accumulation in the lungs. Their work on IBD, also published in 2024, introduced the "algae-MΦNP-robot" system to regulate colonic cytokines and restore the epithelial barrier, garnering 66 citations for addressing the limitations of conventional cytokine-targeted therapies. Yu’s research uniquely combines synthetic biology, nanotechnology, and robotics to create active, biocompatible delivery platforms that enhance therapeutic efficacy while minimizing side effects. With these highly cited studies, Yu has established themselves as a leader in biohybrid microrobotics, offering transformative solutions for precision medicine in oncology and gastroenterology. Their work holds significant promise for advancing targeted treatments in complex disease microenvironments.