Wayne A. Hendrickson
Howard Hughes Medical Institute, Brookhaven National Laboratory
Papers
2
Total Citations
115
H-Index
2
About
Wayne A. Hendrickson is a towering figure in structural biology, renowned for his pioneering contributions to macromolecular crystallography and the atomic-level understanding of complex biological systems. His research centers on the structure and function of proteins, with a particular focus on membrane proteins, viral glycoproteins, and the development of advanced crystallographic methods. Hendrickson’s most celebrated achievement is the elucidation of the structure of gp120, the exterior envelope glycoprotein of HIV-1, a feat that required overcoming formidable barriers posed by the protein’s extensive glycosylation and conformational mobility. His landmark 1999 paper on the probability analysis of variational crystallization of gp120, which has garnered over 112 citations, provided a foundational blueprint for targeting this critical viral component, directly impacting the design of HIV vaccines and therapeutics. Beyond this, Hendrickson has driven the development of next-generation synchrotron beamlines, including the FMX and AMX macromolecular crystallography beamlines at NSLS-II, which enable micro-crystallography and highly automated data collection. His work has earned him numerous accolades, including election to the National Academy of Sciences, and his structural insights continue to illuminate fundamental biological processes and guide drug discovery.
Research Focus
Key Achievements
Top Papers
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