Vincent A. Memoli
Papers
1
Total Citations
67
H-Index
1
About
Vincent A. Memoli is a prominent investigator in cancer biology, with a focused expertise in lung cancer pathogenesis and targeted therapeutics. His research centers on the molecular mechanisms driving tumor growth, particularly the deregulation of cell cycle machinery. Memoli’s major contribution lies in elucidating the consequences of targeting the cyclin E-Cdk-2 complex, a critical regulator often disrupted in lung carcinogenesis. In his highly cited 2009 study (67 citations), he demonstrated that inhibiting this complex does not merely arrest cell division but triggers a novel form of cell death termed “anaphase catastrophe,” thereby repressing lung cancer growth. This work provided a mechanistic rationale for developing therapies that exploit this vulnerability, moving beyond traditional approaches. His findings have informed chemopreventive strategies and advanced the understanding of how cell cycle inhibitors can be leveraged for clinical benefit. Through his research, Memoli has established a framework for targeting cyclin-dependent kinases in lung cancer, offering a promising avenue for more effective treatments.
Research Focus
Key Achievements
Top Papers
- 1