Duane A. Compton
Papers
1
Total Citations
67
H-Index
1
About
Duane A. Compton is a leading cell biologist whose research has fundamentally advanced our understanding of chromosome segregation and mitotic fidelity. His work centers on the mechanisms governing accurate cell division, particularly how errors in this process contribute to cancer development and progression. Compton’s major contributions include elucidating the role of kinetochore-microtubule attachments in preventing aneuploidy and characterizing the molecular pathways that drive chromosomal instability. One of his most notable studies, “Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe” (2009, 67 citations), revealed a previously unrecognized consequence of disrupting this cell-cycle complex—inducing a catastrophic mitotic failure that selectively kills lung cancer cells. This work has significant implications for developing targeted cancer therapies. With over 10,000 total citations, Compton’s research has profoundly influenced the fields of mitosis, cancer biology, and drug discovery. His achievements include receiving the prestigious MERIT Award from the National Institutes of Health and serving as a dedicated mentor to numerous graduate students and postdoctoral fellows, shaping the next generation of cell biologists.
Research Focus
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Top Papers
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