Patricia Greninger
Papers
1
Total Citations
67
H-Index
1
About
Patricia Greninger is a cancer biologist whose work has illuminated critical vulnerabilities in lung cancer by targeting cell cycle regulators. Her research centers on the molecular mechanisms driving tumor growth, with a particular focus on cyclin-dependent kinases (Cdks) and cyclins—proteins frequently deregulated in lung carcinogenesis. In her highly cited 2009 study (67 citations), Greninger demonstrated that disrupting the cyclin E-Cdk-2 complex in lung cancer cells triggers "anaphase catastrophe," a novel cell death pathway that suppresses tumor progression. This work revealed previously unrecognized consequences of Cdk inhibition, offering a compelling rationale for developing targeted therapies against this complex. By uncovering how cell cycle interference can selectively kill cancer cells, Greninger has contributed foundational insights for chemoprevention and therapeutic strategies in lung cancer. Her research bridges basic cell cycle biology and translational oncology, providing a framework for designing drugs that exploit mitotic vulnerabilities. For students and researchers, her work exemplifies how dissecting the nuances of cell cycle control can lead to innovative approaches for combating one of the deadliest cancers.
Research Focus
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