Victor W. Pike
Papers
2
Total Citations
38
H-Index
2
About
Victor W. Pike is a pioneering radiochemist whose career has been dedicated to the development of novel radiotracers for positron emission tomography (PET) imaging, with a profound impact on neuroscience and drug discovery. His research focuses on the design and automated radiosynthesis of carbon-11 and fluorine-18 labeled compounds to visualize and quantify neuroreceptor systems in the living human brain. A key contribution is his work on [¹⁸F]SPA-RQ, a radioligand for imaging neurokinin type-1 (NK₁) receptors, which he successfully automated for clinical production under an IND, enabling its use in human studies and drug development (31 citations). Pike has also advanced the field through innovative labeling methodologies, such as Pd(0)-mediated ¹¹C-carbonylative coupling to synthesize candidate PET radioligands for the histamine subtype-3 receptor, demonstrating his ability to solve complex synthetic challenges. With a career spanning decades at the National Institutes of Health, his work has been instrumental in translating basic radiochemistry into tools for clinical research, earning him recognition as a leader in the development of PET imaging agents for studying brain function and disease.
Research Focus
Key Achievements
Top Papers
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