Tony Pawson
Papers
2
Total Citations
163
H-Index
2
About
Tony Pawson was a pioneering figure in cell signaling research, whose work fundamentally advanced our understanding of how cells communicate and respond to their environment. His laboratory made landmark contributions to the study of modular protein interaction domains, particularly SH2 (Src Homology 2) domains, which recognize phosphorylated tyrosine residues and serve as critical mediators of intracellular signaling cascades. Pawson's research illuminated how receptor tyrosine kinases, such as the Eph family of receptors, orchestrate complex downstream signaling networks by recruiting specific intracellular targets — work reflected in his highly cited study on EphB2 regulatory motifs and MAPK signaling, which garnered 70 citations. His investigations into scaffold proteins like CD2-associated protein (CD2AP) further revealed how molecular scaffolds maintain tissue integrity, including the kidney filtration barrier, earning 93 citations and opening new avenues in renal biology. Collectively, Pawson's contributions helped establish the conceptual framework of modular signaling networks, profoundly influencing how researchers study cancer, developmental biology, and disease. His legacy continues to shape modern biochemistry and translational medicine worldwide.
Research Focus
Key Achievements
Top Papers
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