Hanspeter Niederstrasser
Papers
1
Total Citations
93
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1
About
Hanspeter Niederstrasser is a cell biologist whose research has significantly advanced our understanding of the molecular architecture of the kidney filtration barrier. His work centers on the cytoskeletal dynamics and scaffolding proteins that maintain podocyte structure and function. His most impactful contribution came from his 2006 study, which identified a novel inhibitory actin-capping protein binding motif within CD2-associated protein (CD2AP). Using mass spectrometry, he uncovered a critical mechanism by which CD2AP, a scaffold essential for kidney health, regulates actin polymerization. This finding, which has garnered 93 citations, provided the first molecular insight into how CD2AP dysfunction leads to glomerular disease. Beyond this seminal work, Niederstrasser has made notable contributions to understanding how actin regulatory proteins control cell shape and motility. His research has been instrumental in bridging the gap between cytoskeletal biochemistry and the pathophysiology of kidney disease, offering potential therapeutic targets for conditions like focal segmental glomerulosclerosis.
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