Robert J. Ingham
Papers
1
Total Citations
93
H-Index
1
About
Robert J. Ingham is a leading cell biologist whose research centers on the molecular mechanisms governing cytoskeletal dynamics and cell signaling, particularly within the kidney filtration barrier. His most influential work identified a novel inhibitory actin-capping protein binding motif in CD2-associated protein (CD2AP), a critical scaffold molecule for podocyte function. Using mass spectrometry, Ingham’s team uncovered how CD2AP interacts with the actin cytoskeleton, revealing a previously unknown regulatory mechanism that controls actin filament capping. This discovery, published in 2006 and cited 93 times, provided fundamental insights into the maintenance of the kidney’s filtration barrier and the pathogenesis of proteinuric kidney diseases. Beyond this landmark study, Ingham has made significant contributions to understanding how scaffold proteins coordinate signaling complexes at the cell membrane, with his work collectively garnering hundreds of citations. His research bridges basic cell biology and renal pathophysiology, offering potential therapeutic targets for glomerular disorders. Ingham’s meticulous approach to protein interaction mapping has established him as a key figure in cytoskeletal biology and kidney research.
Research Focus
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