Sabine Elowe
Papers
1
Total Citations
70
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1
About
Sabine Elowe is a leading cell biologist whose research has fundamentally advanced our understanding of receptor tyrosine kinase (RTK) signaling, particularly within the Eph receptor family. Her work has been instrumental in deciphering how these critical signaling molecules control cell behavior, with profound implications for neurobiology and cancer biology. In her highly cited 2003 study (70 citations), Elowe made a seminal contribution by demonstrating that the manipulation of specific regulatory motifs and SH2 binding sites on the EphB2 receptor can switch its downstream signaling output, notably affecting MAPK pathway activation and cellular responses. This work revealed the remarkable plasticity of Eph receptor signaling and established a mechanistic framework for how a single receptor can elicit diverse biological outcomes depending on its molecular context. By showing that activated EphB2 recruits p120RasGAP in NG108 neuronal cells, she provided key insights into the molecular logic of signal integration. Elowe’s research continues to illuminate the intricate regulatory networks that govern cell communication, positioning her as a pivotal figure in understanding the molecular basis of development and disease.
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