Todd M. Branch
Papers
1
Total Citations
94
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1
About
Dr. Todd M. Branch is a pioneer in bioanalytical chemistry, whose work has fundamentally transformed high-throughput sample preparation for mass spectrometry. His primary research focuses on automating liquid-liquid extraction (LLE) and solid-phase extraction (SPE) to accelerate pharmaceutical and clinical analysis. Dr. Branch’s most impactful contribution is the development of a fully automated 96-well LLE methodology, detailed in his seminal 2000 paper (94 citations). By integrating a 96-well plate packed with inert diatomaceous earth with a robotic liquid handling workstation, he eliminated manual, time-consuming steps, enabling the rapid, parallel processing of biological samples. This innovation dramatically increased throughput and reproducibility for liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays. His work has become a cornerstone in drug discovery and therapeutic drug monitoring, directly influencing how laboratories handle large-scale pharmacokinetic studies. Dr. Branch’s contributions have not only advanced analytical efficiency but also set a new standard for robustness in bioanalysis, cementing his legacy as a key architect of modern automated sample preparation.
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