Salane King

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About

Salane King has made transformative contributions to bioanalytical chemistry, particularly in the automation of sample preparation for mass spectrometry. Her landmark 2000 paper, "Fully Automated 96-Well Liquid−Liquid Extraction for Analysis of Biological Samples by Liquid Chromatography with Tandem Mass Spectrometry," introduced a groundbreaking high-throughput liquid-liquid extraction (LLE) methodology using a 96-well filter plate packed with inert diatomaceous earth, paired with a 96-channel robotic workstation. This work, cited 94 times, revolutionized biological sample processing by dramatically reducing manual labor, solvent use, and analysis time while maintaining extraction efficiency and reproducibility. King’s innovation enabled the rapid, reliable preparation of complex biological matrices for LC-MS/MS, a critical advancement for pharmacokinetics, drug metabolism, and clinical diagnostics. Her contributions have been instrumental in accelerating pharmaceutical development and biomarker discovery, setting a new standard for automated bioanalysis. By bridging engineering and analytical chemistry, King’s work continues to influence modern high-throughput laboratories, empowering researchers to process hundreds of samples with precision and speed. Her legacy lies in making robust, automated sample preparation accessible, profoundly impacting the efficiency of quantitative bioanalysis.