Papers
3
Total Citations
165
H-Index
3
About
Sean Peng is a pioneering researcher in the field of high-throughput bioanalytical chemistry, with a particular focus on automated sample preparation methodologies for pharmaceutical and combinatorial chemistry applications. His most influential contribution, "Fully Automated 96-Well Liquid−Liquid Extraction for Analysis of Biological Samples by Liquid Chromatography with Tandem Mass Spectrometry" (2000), garnered 94 citations and introduced a transformative approach to biological sample preparation by integrating 96-well filter plate technology with robotic liquid handling systems — dramatically accelerating drug discovery workflows. Building on this foundation, his 1999 work on automated high-throughput liquid−liquid extraction for purifying combinatorial libraries (52 citations) demonstrated the broad applicability of his techniques across medicinal chemistry pipelines. His 2005 invention of a novel 96-well screen filter plate further refined in vivo sample handling by eliminating cumbersome clot-removal steps that hampered accuracy and throughput. Collectively, Peng's research has meaningfully advanced the efficiency and reliability of LC-MS/MS bioanalysis, making him a notable contributor to the automation revolution in pharmaceutical sample processing. His work remains a valuable reference for researchers developing streamlined drug metabolism and pharmacokinetics (DMPK) workflows.
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