Takumi Hara
Papers
1
Total Citations
7
H-Index
1
About
Dr. Takumi Hara has made significant contributions to genetic toxicology, particularly in the development and refinement of high-throughput genotoxicity screening assays. His most cited work focuses on the improvement and evaluation of the fluctuation Ames test, a critical method for detecting mutagenic potential of compounds. Hara advanced this assay by adapting it to a 384-well plate format using *Salmonella typhimurium* strains TA100 and TA98, dramatically increasing throughput while reducing compound requirements and testing time. This innovation addressed the growing need for rapid, efficient genotoxicity screening in early drug discovery, especially with the rise of combinatorial chemistry and robotics. His work has garnered attention from researchers seeking to balance speed with accuracy in toxicological assessment, accumulating citations that underscore its practical utility. By enabling faster, more resource-efficient mutagenicity testing, Hara’s contributions have helped streamline preclinical safety evaluations, making him a notable figure in the field of genetic toxicology and assay development.
Research Focus
Key Achievements
Top Papers
- 1