Kumiko Kawakami
Papers
1
Total Citations
7
H-Index
1
About
Kumiko Kawakami is a leading figure in genetic toxicology, whose work has significantly advanced the high-throughput screening of chemical mutagens. Her primary research focuses on developing and refining rapid, sensitive genotoxicity assays to meet the demands of modern drug discovery. Her most impactful contribution is the improvement and evaluation of the high-throughput fluctuation Ames test, a critical tool for detecting DNA-damaging compounds. By adapting this assay for use with 384-well plates and the bacterial strains *Salmonella typhimurium* TA100 and TA98, Kawakami enabled researchers to screen large chemical libraries with minimal compound quantities and drastically reduced turnaround times. This innovation directly addresses the need for faster, more efficient preclinical safety assessments, allowing for earlier identification of potential carcinogens. Her work, which has garnered citations from peers in toxicology and pharmaceutical development, has become a methodological benchmark for laboratories seeking to balance throughput with reliability. Kawakami’s achievements have helped bridge the gap between traditional, labor-intensive mutagenicity testing and the high-speed demands of combinatorial chemistry and automated robotics, solidifying her role as an essential innovator in the field.
Research Focus
Key Achievements
Top Papers
- 1