Susan Henning
Papers
2
Total Citations
320
H-Index
2
About
Susan Henning’s pioneering research has fundamentally shaped our understanding of intestinal development, cellular homeostasis, and the molecular mechanisms governing gut maturation. Her key contributions center on the genetic regulation of intestinal epithelial cell fate and the role of glucocorticoid signaling in the developing small intestine. Henning’s landmark 2007 study, cited over 300 times, demonstrated that intestine-specific ablation of the transcription factor Math1 (Atoh1) disrupts cellular homeostasis, revealing its critical role in directing secretory cell lineage specification. This work provided foundational insights into how the intestine maintains its complex cellular architecture. Henning also advanced knowledge of glucocorticoid-induced intestinal maturation, identifying 66 rapidly induced transcripts in the developing jejunum through microarray analyses, thereby elucidating the molecular pathways underlying functional gut development. Her research has had lasting impact on developmental biology and gastroenterology, informing studies on intestinal stem cell biology, tissue regeneration, and diseases such as colorectal cancer. Henning’s rigorous genetic approaches and integrative analyses continue to inspire researchers exploring the intricate regulatory networks that orchestrate intestinal health and disease.
Research Focus
Key Achievements
Top Papers
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